Fig. 1 · Structure
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5-HT2A/5-HT2C inverse agonist 1
5-HT2A/5-HT2C Receptor Inverse Agonist
5-HT2A/5-HT2C inverse agonist 1 functions as a potent dual inverse agonist at the 5-HT2A and 5-HT2C receptors, demonstrating minimal hERG channel inhibition to mitigate cardiovascular risks. This compound exhibits significant antipsychotic effects in the MK-801-induced mouse model, making it a valuable tool for the investigation of psychotic disorders. It is particularly relevant for studies aiming to elucidate the molecular mechanisms underlying psychosis and for the development of new therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inverse Agonist |
| CAS Number | 2718990-76-0 |
| Applications | 5-HT2A/5-HT2C Receptor Inverse Agonist |
| Formula | C24H35N5O2 |
| Molecular Weight | 425.57 |
| SMILES | CN(C=C1)N=C1CN([C@@H]2C3(CN(CC2)C)CC3)C(NCC4=CC=C(C=C4)OCCC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.