5-HT6/5-HT2AR antagonist-1

Catalog No.: A29784
5-HT6/5-HT2AR Antagonist
5-HT6/5-HT2AR antagonist-1 is a potent dual antagonist targeting the 5-HT6 and 5-HT2A receptors, exhibiting Ki values of 11 nM and 39 nM, respectively. This compound's inhibition of serotonergic signaling pathways is relevant in the study of neuropsychiatric disorders and cognitive function. Its dual-action mechanism makes it a valuable tool for researchers exploring the therapeutic potential in conditions such as schizophrenia and Alzheimer's disease.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description5-HT6/5-HT2AR antagonist-1 is a potent dual antagonist targeting the 5-HT6 and 5-HT2A receptors, exhibiting Ki values of 11 nM and 39 nM, respectively. This compound's inhibition of serotonergic signaling pathways is relevant in the study of neuropsychiatric disorders and cognitive function. Its dual-action mechanism makes it a valuable tool for researchers exploring the therapeutic potential in conditions such as schizophrenia and Alzheimer's disease.
Product Information
Catalog NumA29784
FormulaC21H26N6S
Molecular Weight394.54
CAS Number2763654-60-8
SMILESNC1=NC(N2CCN(C)CC2)=NC(C(C)(SC3=CC=C4C=CC=CC4=C3)C)=N1
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