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5-HT7/5-HT2A receptor antagonist 1

5-HT7/5-HT2A Receptor Antagonist

5-HT7/5-HT2A receptor antagonist 1 is a high-affinity ligand targeting both the 5-HT7 and 5-HT2A receptors, demonstrating oral bioavailability and significant brain permeability with a pKi of 8.1. This compound functions as an antagonist in in vitro assays for the 5-HT2A receptor and as an inverse agonist for the 5-HT7 receptor. In vivo studies have shown that it effectively blocks 5-Carboxamidotryptamine (5-CT)-induced hypothermia in rats and DOI-induced head-twitches in mice, while it also occupies 5-HT2A receptor binding sites in the frontal cortex. 5-HT7/5-HT2A receptor antagonist 1 is suitable for investigating neuropharmacological disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	851375-22-9
Applications	5-HT7/5-HT2A Receptor Antagonist
Formula	C₁₆H₂₀FN₃
Molecular Weight	273.35
SMILES	CC(C)N1C(C2=CC=C(F)C=C2)=C3C(CCNCC3)=N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.