5-HT7R Antagonist 3 is a selective antagonist of the 5-HT7 receptor, exhibiting a Ki value of 8 nM, which illustrates its high affinity for the target. It shows lower affinity for other receptors, such as D2 (Ki: 511 nM), 5-HT1A (Ki: 8930 nM), and 5-HT2A (Ki: 5786 nM). This compound demonstrates significant antidepressant and anxiolytic effects in murine models, making it a valuable tool for research in mood disorders and anxiety-related conditions.
5-HT7R Antagonist 3 is a selective antagonist of the 5-HT7 receptor, exhibiting a Ki value of 8 nM, which illustrates its high affinity for the target. It shows lower affinity for other receptors, such as D2 (Ki: 511 nM), 5-HT1A (Ki: 8930 nM), and 5-HT2A (Ki: 5786 nM). This compound demonstrates significant antidepressant and anxiolytic effects in murine models, making it a valuable tool for research in mood disorders and anxiety-related conditions.
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