Fig. 1 · Structure
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5-Hydroxy Propafenone hydrochloride
Ito Inhibitor
5-Hydroxy Propafenone hydrochloride is a potent inhibitor of the transient outward potassium current (Ito) in cardiac myocytes. As an active metabolite of propafenone, it effectively reduces repolarizing currents, demonstrating an IC50 of 1.5 μM in isolated human arterial myocytes. This reagent is particularly relevant for research applications involving cardiac electrophysiology and the study of arrhythmias in both neonatal rat ventricular myocytes and human tissues.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 86383-32-6 |
| Applications | Ito Inhibitor |
| Formula | C21H28ClNO4 |
| Molecular Weight | 393.90 |
| Synonyms | GPV-129 hydrochloride |
| SMILES | [H]Cl.O=C(C1=CC(O)=CC=C1OCC(O)CNCCC)CCC2=CC=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.