Fig. 1 · Structure
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5-Hydroxydiclofenac
Metabolite of Diclofenac
5-Hydroxydiclofenac is a significant metabolite of Diclofenac, primarily generated by the cytochrome P450 isoforms CYP3A4, CYP2C19, CYP2C8, and CYP2C18. This compound exhibits apoptotic effects in hepatocytes, making it a valuable tool for investigating liver-related pathologies and drug metabolism. Its role in the pharmacokinetics of Diclofenac provides important insights for research in toxicology and pharmacology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 69002-84-2 |
| Applications | Metabolite of Diclofenac |
| Formula | C14H11Cl2NO3 |
| Molecular Weight | 312.15 |
| SMILES | O=C(CC1=CC(O)=CC=C1NC2=C(Cl)C=CC=C2Cl)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.