Fig. 1 · Structure
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5-Methyluridine
RNA nucleoside
5-Methyluridine (m5U) is an RNA modified nucleotide that acts as a substrate for RNA methyltransferases, including TrmA and RumA, which specifically modify uracil residues in RNA. This nucleoside plays a critical role in enhancing translation accuracy and ribosome function through stabilization of RNA structures, particularly in the T arm of tRNA and specific regions of rRNA. Applications in research include studies on RNA processing, modification impact on ribosomal activities, and exploration of RNA secondary and tertiary structure influences.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 1463-10-1 |
| Applications | RNA nucleoside |
| Formula | C10H14N2O6 |
| Molecular Weight | 258.23 |
| SMILES | O[C@H]1[C@@H](O)[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1CO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.