Fig. 1 · Structure
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5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
DNA/RNA Synthesi
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) serves as a competitive inhibitor of E. coli dUTP nucleotidohydrolase (dUTPase), exhibiting a Ki value greater than 1000 μM. This reagent is integral to machine-assisted DNA synthesis, facilitating the production of nucleosidic phosphoramidite blocks for oligonucleotide assembly. Its application is pivotal for researchers in molecular biology and genetics, particularly in the development and optimization of DNA synthesis protocols.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 23669-79-6 |
| Applications | DNA/RNA Synthesi |
| Formula | C30H30N2O7 |
| Molecular Weight | 530.57 |
| Synonyms | 5'-O-DMT-dU |
| SMILES | COC1=CC=C(C(C2=CC=C(OC)C=C2)(OC[C@@H]3[C@@H](O)C[C@@H](O3)N4C=CC(NC4=O)=O)C5=CC=CC=C5)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.