Fig. 1 · Structure
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5'-O-DMT-N4-Bz-2'-F-dC
Nucleoside
5'-O-DMT-N4-Bz-2'-F-dC is a modified nucleoside featuring a protective 5'-O-DMT group and a benzoyl (Bz) modification at the N4 position, along with a 2'-fluoro substitution. This compound exhibits enhanced stability and plays a crucial role in oligonucleotide synthesis and molecular biology applications. Its unique structural properties make it valuable for the development of antisense therapeutics and RNA interference studies, facilitating more effective gene expression modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 146954-77-0 |
| Applications | Nucleoside |
| Formula | C37H34FN3O7 |
| Molecular Weight | 651.68 |
| SMILES | O[C@@H]([C@@H](F)[C@H](N1C(N=C(NC(C2=CC=CC=C2)=O)C=C1)=O)O3)[C@H]3COC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.