Fig. 1 · Structure
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5'-O-TBDMS-dT
Nucleoside
5'-O-TBDMS-dT is a nucleoside modified with a tert-butyldimethylsilyl (TBDMS) protecting group at the 5' position. This compound is instrumental in the synthesis of oligonucleotides, enabling selective modifications while preserving nucleoside integrity. Its primary applications include the development of RNA and DNA polymers in biochemical research, as well as in the creation of modified nucleotides for therapeutic explorations.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 40733-28-6 |
| Applications | Nucleoside |
| Formula | C16H28N2O5Si |
| Molecular Weight | 356.49 |
| SMILES | O[C@H]1C[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1CO[Si](C)(C)C(C)(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.