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5'-VP-2'-OMe-U phosphoramidite

Biochemical Reagent

5'-VP-2'-OMe-U phosphoramidite is a specialized phosphoramidite featuring a 5' dimethoxytrityl (DMT) group and a 2'-O-methyl protected uridine. This reagent is essential for the synthesis of modified oligonucleotides, enabling researchers to introduce 2'-O-methylation into RNA oligonucleotides, which can enhance stability and reduce immunogenicity. Its applications span various fields, including gene therapy, RNA interference, and oligonucleotide-based diagnostics.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1882067-09-5
Applications	Biochemical Reagent
Formula	C₃₂H₅₂N₄O₁₃P₂
Molecular Weight	762.72
SMILES	CO[C@@H]1[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](/C=C/P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)O[C@H]1N2C=CC(NC2=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.