Fig. 1 · Structure
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6,8-Diprenylnaringenin
ABCG2 Inhibitor
6,8-Diprenylnaringenin is a potent inhibitor of the breast cancer resistance protein (BCRP/ABCG2), a key player in drug transport and resistance mechanisms. This hop-derived prenylflavonoid effectively obstructs ABCG2-mediated efflux of various substrates, including Mitoxantrone and 3H-Methotrexate, with an IC50 value of 0.41 μM in HEK293 cells. Additionally, 6,8-Diprenylnaringenin demonstrates limited estrogenic activity, exhibiting less than 1% of the potency of 8-Prenylnaringenin, making it a valuable tool for studying drug resistance and hormone-related research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 68236-11-3 |
| Applications | ABCG2 Inhibitor |
| Formula | C25H28O5 |
| Molecular Weight | 408.49 |
| Synonyms | Lonchocarpol A; Senegalensin |
| SMILES | O=C1C[C@H](OC2=C(C(O)=C(C(O)=C12)C/C=C(C)\C)C/C=C(C)\C)C3=CC=C(C=C3)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.