Fig. 1 · Structure
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6-Amino-8-trifluoromethylphenanthridine
Prion Protein Inhibitor
6-Amino-8-trifluoromethylphenanthridine is a prion protein inhibitor that acts by disrupting protein folding activity on the ribosomal machinery, specifically targeting the ribosomal active site. At a concentration of 150 μM, it effectively competes with protein substrates, thereby influencing prion-related pathways. This compound holds potential for research applications in studying prion diseases and protein misfolding mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 651055-83-3 |
| Applications | Prion Protein Inhibitor |
| Formula | C14H9F3N2 |
| Molecular Weight | 262.23 |
| Synonyms | 6A-8tFP |
| SMILES | NC1=C2C=C(C(F)(F)F)C=CC2=C(C=CC=C3)C3=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.