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6-Iodoamiloride

ASIC1 Inhibitor

6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM. This compound effectively inhibits ASIC3-mediated currents in rat dorsal root ganglion neurons, with an IC50 of 230 nM. It is valuable for research applications focused on pain mechanisms, neurobiology, and disorders associated with altered proton sensing.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	60398-23-4
Applications	ASIC1 Inhibitor
Formula	C₆H₈IN₇O
Molecular Weight	321.08
SMILES	NC1=C(C(NC(N)=N)=O)N=C(I)C(N)=N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.