Fig. 1 · Structure
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6-Methoxydihydrosanguinarine
Anti-Cancer Agent
6-Methoxydihydrosanguinarine is an alkaloid that serves as an anti-cancer agent by targeting multiple signaling pathways. It activates the IRE1/JNK pathway while inhibiting the Akt/mTOR and PI3K/AKT/mTOR pathways, leading to decreased expression of key proteins associated with cell cycle regulation and survival, such as Cdc25C, CyclinB1, Cdc2, YAP/TAZ, Survivin, and EGFR. This compound effectively induces apoptosis, G2/M phase arrest, DNA damage, and lipid peroxidation, contributing to its potential against various cancers, including non-small cell lung cancer, hepatocellular carcinoma, melanoma, colon carcinoma, ovarian cancer, and breast cancer. Additionally, 6-Methoxydihydrosanguinarine has demonstrated activity in disrupting the biofilm formation of Candida albicans.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 72401-54-8 |
| Applications | Anti-Cancer Agent |
| Formula | C21H17NO5 |
| Molecular Weight | 363.36 |
| SMILES | CN1C2=C3C(C=C4OCOC4=C3)=CC=C2C5=C(C6=C(OCO6)C=C5)C1OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.