Fig. 1 · Structure
Documents & Downloads
6bK TFA
IDE Inhibitor
6bK TFA is a potent and selective inhibitor of insulin degrading enzyme (IDE), with an IC50 value of 50 nM. This compound effectively increases circulating insulin levels in high-fat-fed mice and enhances glucose tolerance following oral glucose administration, particularly in this model. 6bK TFA is valuable for research applications related to type 2 diabetes and the modulation of insulin signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1774353-12-6 |
| Applications | IDE Inhibitor |
| Formula | C43H56F3N7O9 |
| Molecular Weight | 871.94 |
| SMILES | O=C(N[C@@H](C(NCCCC[C@H]1C(N)=O)=O)CC(C=C2)=CC=C2C(C3=CC=CC=C3)=O)[C@@H](NC([C@@H](NC(/C=C/C(N1)=O)=O)CCCCN)=O)CC4CCCCC4.OC(C(F)(F)F)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.