Fig. 1 · Structure
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6PPD-Q (6PPD-Quinone)
CNR2 Receptor Agonist
6PPD-Q (6PPD-Quinone) is an environmental pollutant ubiquitously detected in various ecosystems and in human biological samples such as urine. It exhibits strong binding affinity toward multiple molecular targets, including CNR2, CNR1, AA2AR, LCAT, and TRPA1, with the highest affinity observed for CNR2, suggesting its potential role as a CNR2 receptor agonist that activates cannabinoid signaling. Mechanistically, 6PPD-Q disrupts mitochondrial function, impairs neuronal energy metabolism by reducing glycolytic and TCA cycle intermediates, and promotes α-synuclein (α-syn) aggregation. These effects contribute to intestinal inflammation and epithelial barrier dysfunction. 6PPD-Q serves as a valuable research compound for studies in environmental toxicology, neurodegeneration, and inflammation-related pathophysiology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2754428-18-5 |
| Applications | CNR2 Receptor Agonist |
| Formula | C18H22N2O2 |
| Molecular Weight | 298.38 |
| Synonyms | 6PPD-Quinone |
| SMILES | O=C1C(NC(C)CC(C)C)=CC(C(NC2=CC=CC=C2)=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.