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(6S)-Tetrahydrofolic acid

Folate Derivative

(6S)-Tetrahydrofolic acid is a potent folate derivative that primarily enhances the binding of fluorodeoxyuridylate to thymidylate synthase, exhibiting 1000-fold greater activity than its (6R) counterpart. Additionally, it demonstrates a remarkable 600-fold increase in its capacity as a growth factor for P. cerevisiae. Its characteristics include low affinity and high dissociation rate for folate-binding protein, making it a valuable tool for research in metabolic and biochemical pathways involving folate metabolism.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	71963-69-4
Applications	Folate Derivative
Formula	C₁₉H₂₃N₇O₆
Molecular Weight	445.43
Synonyms	(6S)-5,6,7,8-Tetrahydrofolic acid
SMILES	O=C1C2=C(NC(N)=N1)NC[C@@H](N2)CNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.