Fig. 1 · Structure
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7,3',4'-Trihydroxyisoflavone
Cot/MKK4 Inhibitor
7,3',4'-Trihydroxyisoflavone is an ATP-competitive inhibitor targeting Cot (Tpl2/MAP3K8) and MKK4. This compound demonstrates significant biological activity, including anticancer, anti-angiogenic, and chemoprotective properties, along with the ability to scavenge free radicals. Research applications include studies on cellular signaling pathways and therapeutic strategies for cancer treatment.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 485-63-2 |
| Applications | Cot/MKK4 Inhibitor |
| Formula | C15H10O5 |
| Molecular Weight | 270.24 |
| SMILES | OC1=CC=C2C(C(C3=CC(O)=C(C=C3)O)=COC2=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.