Fig. 1 · Structure
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7-Hydroxy-2,2-dimethyl-4-chromanone
DC-SIGN Inhibitor
7-Hydroxy-2,2-dimethyl-4-chromanone is a potent inhibitor of DC-SIGN (Dendritic Cell-Specific Intercellular Adhesion Molecule 3 grabbing non-integrin), exhibiting an IC50 of 4.66 mM. As a C-type lectin receptor, DC-SIGN plays a crucial role in mediating immune responses by facilitating interactions between dendritic cells and pathogens. This compound is valuable for research applications aimed at understanding immune signaling pathways and developing potential therapeutic strategies targeting DC-SIGN-related processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 17771-33-4 |
| Applications | DC-SIGN Inhibitor |
| Formula | C11H12O3 |
| Molecular Weight | 192.21 |
| SMILES | O=C1CC(C)(C)OC2=C1C=CC(O)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.