Fig. 1 · Structure
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7-Hydroxystaurosporine
PKC Inhibitor
7-Hydroxystaurosporine is a selective protein kinase C (PKC) inhibitor known for its significant antitumor activity. This compound induces apoptosis and inhibits cell proliferation in colon carcinoma and leukemia cells, while also suppressing invasion and migration in glioblastoma cells. Additionally, 7-hydroxystaurosporine demonstrates efficacy in breast cancer xenograft mouse models, making it a valuable tool for research into colon carcinoma, breast cancer, glioblastoma, and leukemia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 112953-11-4 |
| Applications | PKC Inhibitor |
| Formula | C28H26N4O4 |
| Molecular Weight | 482.53 |
| Synonyms | UCN-01; KRX-0601 |
| SMILES | C[C@]12N3C4=C(C5=CC=CC=C53)C([C@H](NC6=O)O)=C6C7=C4N([C@](C[C@H]([C@H]2OC)NC)([H])O1)C8=CC=CC=C78 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.