Fig. 1 · Structure
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7BIO
Indirubin Derivate
7BIO (7-Bromoindirubin-3-Oxime) is a derivative of indirubin that primarily targets cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β). This compound exhibits significant inhibitory effects, leading to the reduction of Aβ oligomer-induced neuroinflammation, synaptic dysfunction, and tau hyperphosphorylation. Additionally, 7BIO attenuates the activation of astrocytes and microglia, as well as cognitive impairments associated with Aβ oligomers, making it a valuable tool for studying neurodegenerative processes and potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 916440-85-2 |
| Applications | Indirubin Derivate |
| Formula | C16H10BrN3O2 |
| Molecular Weight | 356.17 |
| Synonyms | 7-Bromoindirubin-3-Oxime |
| SMILES | O/N=C1C2=CC=CC=C2NC\1=C3C(NC4=C(C=CC=C4/3)Br)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.