7rh is a selective inhibitor of discoidin domain receptor 1 (DDR1), exhibiting an IC50 of 13.1 nM, and also demonstrates moderate inhibitory activity against DDR2 with an IC50 of 203 nM. This compound serves as a valuable tool for the study of receptor signaling and cellular processes associated with DDRs. Additionally, 7rh incorporates an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, making it suitable for applications in click chemistry.
7rh is a selective inhibitor of discoidin domain receptor 1 (DDR1), exhibiting an IC50 of 13.1 nM, and also demonstrates moderate inhibitory activity against DDR2 with an IC50 of 203 nM. This compound serves as a valuable tool for the study of receptor signaling and cellular processes associated with DDRs. Additionally, 7rh incorporates an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, making it suitable for applications in click chemistry.
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