Fig. 1 · Structure
Documents & Downloads
7rh
DDR Inhibitor
7rh is a selective inhibitor of discoidin domain receptor 1 (DDR1), exhibiting an IC50 of 13.1 nM, and also demonstrates moderate inhibitory activity against DDR2 with an IC50 of 203 nM. This compound serves as a valuable tool for the study of receptor signaling and cellular processes associated with DDRs. Additionally, 7rh incorporates an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, making it suitable for applications in click chemistry.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1429617-90-2 |
| Applications | DDR Inhibitor |
| Formula | C30H29F3N6O |
| Molecular Weight | 546.59 |
| Synonyms | DDR1-IN-2 |
| SMILES | O=C(NC1=CC(C(F)(F)F)=CC(CN2CCN(C)CC2)=C1)C3=CC=C(CC)C(C#CC4=CN5C(N=C4)=CC=N5)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.