Fig. 1 · Structure
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(7S)-BAY-593
GGTase-I Inhibitor
(7S)-BAY-593 is a potent inhibitor of geranylgeranyltransferase I (GGTase-I), specifically the S-enantiomer of BAY-593. This compound effectively disrupts YAP1/TAZ signaling pathways, demonstrating significant antitumor activity in animal models. It serves as a valuable tool for cancer research, particularly in studies focused on the regulation of the Hippo signaling pathway and its implications in tumorigenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2413068-25-2 |
| Applications | GGTase-I Inhibitor |
| Formula | C26H31F3N2O3 |
| Molecular Weight | 476.53 |
| SMILES | O=C(N1CCC2(CCNC[C@]2([H])C3=CC=CC=C3OC)CC1)[C@@](OC)(C(F)(F)F)C4=CC=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.