Fig. 1 · Structure
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8-Azaadenosine
ADAR1 Inhibitor
8-Azaadenosine is a potent inhibitor of ADAR1, effectively blocking A-to-I RNA editing processes. This compound has been shown to inhibit cellular proliferation, three-dimensional growth, invasion, and migration in thyroid cancer cells, making it a valuable tool in cancer research. Its ability to modulate RNA editing provides insights into mechanisms of tumor progression and potential therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 10299-44-2 |
| Applications | ADAR1 Inhibitor |
| Formula | C9H12N6O4 |
| Molecular Weight | 268.23 |
| SMILES | NC1=NC=NC2=C1N=NN2[C@@H]3O[C@@H]([C@H]([C@H]3O)O)CO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.