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8-Azido-ADP disodium

Mitochondrial Adenine Nucleotide Translocation Inhibitor

8-Azido-ADP disodium is a covalent-binding inhibitor targeting mitochondrial adenine nucleotide translocation. It irreversibly inhibits adenine nucleotide exchange in a light-dependent manner, disrupting the state 4 to 3 transitions of mitochondrial respiration triggered by ADP. Additionally, 8-Azido-ADP disodium serves as a versatile click chemistry reagent, featuring an azide group that participates in copper-catalyzed azide-alkyne cycloadditions and strain-promoted alkyne-azide cycloadditions with alkyne-bearing molecules. This compound is valuable for studying mitochondrial function and developing biochemical probes.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	102185-14-8
Applications	Mitochondrial Adenine Nucleotide Translocation Inhibitor
Formula	C₁₀H₁₂N₈Na₂O₁₀P₂
Molecular Weight	512.18
SMILES	O[C@@H]1[C@H](O)[C@@H](COP(OP(O)(O[Na])=O)(O[Na])=O)O[C@H]1N2C3=NC=NC(N)=C3N=C2N=[N+]=[N-]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

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Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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8-Azido-ADP disodium

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