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8-Br-cADPR

cADPR Antagonist

8-Br-cADPR (8-Bromo-Cyclic ADP-Ribose) is a potent antagonist of cyclic adenosine diphosphate ribose (cADPR), targeting the TRPM2 ion channel. This compound demonstrates significant biological activity by reducing renal damage and inhibiting the expression of caspase-3 and TRPM2. It serves as a valuable tool in research focused on cellular calcium signaling, apoptosis, and renal pathophysiology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	151898-26-9
Applications	cADPR Antagonist
Formula	C₁₅H₂₀BrN₅O₁₃P₂
Molecular Weight	620.20
Synonyms	8-Bromo-Cyclic ADP-Ribose
SMILES	O[C@H]1[C@@H](O)[C@H](N2C(Br)=NC3=C2N=CN([C@H]4[C@H](O)[C@H](O)[C@@H](COP(O5)(O)=O)O4)C3=N)O[C@@H]1COP5(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.