Fig. 1 · Structure
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8-Geranyloxypsoralen
Cytochrome P450 Inhibitor
8-Geranyloxypsoralen is a furanocoumarin that serves as a potent inhibitor of cytochrome P450 3A4 (CYP3A4), exhibiting an IC50 value of 3.93 μM. This compound is commonly utilized in research to explore drug metabolism and potential interactions involving CYP3A4, which plays a critical role in the biotransformation of numerous therapeutic agents. The inhibition of CYP3A4 by 8-Geranyloxypsoralen can facilitate the study of pharmacokinetics and enzyme regulation in cellular models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 7437-55-0 |
| Applications | Cytochrome P450 Inhibitor |
| Formula | C21H22O4 |
| Molecular Weight | 338.40 |
| SMILES | O=C1C=CC2=CC3=C(OC=C3)C(OC/C=C(C)/CC/C=C(C)/C)=C2O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.