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8BTC

Notum Inhibitor

8BTC is a potent covalent inhibitor of Notum, exhibiting an IC50 value of 2.5 nM. This compound primarily functions by inhibiting the deacylation of Wnt proteins, thereby modulating Wnt signaling pathways. It is valuable for research applications focused on understanding the role of Wnt signaling in various biological processes and diseases, including cancer and developmental disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3064070-24-9
Applications	Notum Inhibitor
Formula	C₁₀H₉Cl₂NO
Molecular Weight	230.09
SMILES	CC(N1CCC2=C1C=CC(Cl)=C2Cl)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.