Fig. 1 · Structure
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8MDP
ENT1 Inhibitor
8MDP is a highly potent inhibitor of the equilibrative nucleoside transporter 1 (ENT1), exhibiting an IC50 value of 0.43 nM. This compound effectively inhibits the uptake of [H3] uridine in both K562 and K15NTD cell lines through the inhibition of human ENT1 and ENT2 transporters. Its specific targeting of ENT1 makes it a valuable tool in research applications focused on nucleoside transport and metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 29491-75-6 |
| Applications | ENT1 Inhibitor |
| Formula | C28H48N8O4 |
| Molecular Weight | 560.73 |
| SMILES | OCCN(CCO)C1=NC(N2CCCCCCC2)=C(N=C(N(CCO)CCO)N=C3N4CCCCCCC4)C3=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.