Fig. 1 · Structure
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9,10-Phenanthrenequinone
Claudin Inhibitor
9,10-Phenanthrenequinone is a potent inhibitor of claudin-5 (CLDN5), exerting its effects through a nitric oxide synthase (NOS) and reactive oxygen species (ROS)-dependent mechanism that induces apoptosis. This compound has been shown to promote endothelial barrier dysfunction by activating caspases, leading to DNA fragmentation, while also reducing CLDN5 expression and implicating proteasomal proteolysis. Its unique activity makes it a valuable tool for research in cell barrier integrity and apoptotic processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 84-11-7 |
| Applications | Claudin Inhibitor |
| Formula | C14H8O2 |
| Molecular Weight | 208.21 |
| SMILES | O=C1C2=CC=CC=C2C3=CC=CC=C3C1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.