Fig. 1 · Structure
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9''-Methyl salvianolate B
g5Rp Inhibitor
9''-Methyl salvianolate B is a potent inhibitor of g5Rp with a high binding affinity (Kd value of 117 nM), demonstrating permeability through the blood-brain barrier. It disrupts the interaction between ASFV g5Rp and host proteins eIF5A or RPS15, restoring hypusination modification of eIF5A and promoting autophagy, thereby inhibiting African swine fever virus replication. Additionally, 9''-Methyl salvianolate B acts as a ZBP1 inhibitor, effectively disrupting ZBP1-mediated PANoptosome assembly and alleviating myocardial ischemia/reperfusion injury. This compound is valuable for research focused on African swine fever and related biological pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1167424-31-8 |
| Applications | g5Rp Inhibitor |
| Formula | C37H32O16 |
| Molecular Weight | 732.64 |
| Synonyms | MSB |
| SMILES | OC1=C(O)C=CC(C[C@H](C(OC)=O)OC([C@H]2C3=C(/C=C/C(O[C@@H](C(O)=O)CC4=CC(O)=C(O)C=C4)=O)C=CC(O)=C3O[C@@H]2C5=CC(O)=C(O)C=C5)=O)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.