Fig. 1 · Structure
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9-Methylguanine
DHPS Inhibitor
9-Methylguanine is a dihydropteroate synthase (DHPS) inhibitor, demonstrating a binding affinity with a Kd of 58 μM for Escherichia coli DHPS (EcDHPS). This compound exhibits significant activity in modulating folate biosynthesis pathways, making it valuable for research in antibiotic resistance and metabolic studies. Its role as an inhibitor allows for exploration of bacterial growth regulation and potential therapeutic applications in microbial infections.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 5502-78-3 |
| Applications | DHPS Inhibitor |
| Formula | C6H7N5O |
| Molecular Weight | 165.16 |
| SMILES | O=C1N=C(N)NC2=C1N=CN2C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.