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(9R)-Exatecan

Drug Derivative

(9R)-Exatecan is a potent inhibitor of DNA topoisomerase I, exhibiting an IC50 of 2.2 μM. As the (1R,9S) stereoisomer of Exatecan, this drug derivative is utilized primarily in cancer research to elucidate mechanisms of tumorigenesis and therapeutic responses. Its activity against topoisomerase I makes it a valuable tool for investigating DNA replication and repair processes in cancer cells.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2489613-17-2
Applications	Drug Derivative
Formula	C₂₄H₂₂FN₃O₄
Molecular Weight	435.45
Synonyms	(9R)-DX8951f
SMILES	N[C@@H]1C2=C3C(C(N4C3)=CC([C@@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.