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A 131701

α1a/α1d-adrenoceptor Antagonist

A 131701 is a selective antagonist of the α1a and α1d-adrenoceptors, exhibiting a Ki value of 0.22 nM for the human α1a receptor. It effectively inhibits epinephrine-induced increases in intraurethral pressure (IUP) and has been shown to induce transient decreases in mean arterial blood pressure (MABP) and transient tachycardia. This compound is valuable for research into spontaneous hypertension and related cardiovascular conditions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	181490-18-6
Applications	α1a/α1d-adrenoceptor Antagonist
Formula	C₂₄H₂₄N₄O₃S
Molecular Weight	448.54
SMILES	O=C1NC(C2=NC=CC=C2S3)=C3C(N1CCN4C[C@]5([H])CCC6=C(OC)C=CC=C6[C@]5([H])C4)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.