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BCL-XL inhibitor

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Catalog No. A16190

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
A-1331852 5mg A16190-5
A-1331852 10mg A16190-10
A-1331852 50mg A16190-50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

A-1331852 is a potent and selective BCL-XL inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML.


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Chemical Information

Catalog Num A16190
Actions Inhibitor
M. Wt 658.82
Formula C38H38N6O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1430844-80-6
Synonyms A 1331852, A1331852

Biological Activity

A-1331852 is a potent and selective BCL-XL inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML.
Bcl-xL Bcl-w Bcl-2 Mcl-1
<0.01 nM(Ki)4 nM(Ki)6 nM(Ki)142 nM(Ki)

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.18 mL 75.89 mL 151.79mL
0.5 mM 3.04 mL 15.18 mL 30.36 mL
1 mM 1.52 mL 7.59 mL 15.18 mL
5 mM 0.3 mL 1.52 mL 3.04 mL

*The above data is based on the productmolecular weight 658.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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