A-1331852

Catalog No.: A16190

BCL-XL inhibitor

A-1331852

A-1331852 Chemical Structure

CAS NO. 1430844-80-6

A-1331852 is a potent and selective BCL-XL inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML.

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$200.00
50 mg
$670.00
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Biological Activity

A-1331852 is a potent and selective BCL-XL inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML.
Targets
Bcl-xL Bcl-w Bcl-2 Mcl-1
<0.01 nM(Ki)4 nM(Ki)6 nM(Ki)142 nM(Ki)
In vitro DMSO 91 mg/mL (138.12 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.18 mL 75.89 mL 151.79 mL
0.5 mM 3.04 mL 15.18 mL 30.36 mL
1 mM 1.52 mL 7.59 mL 15.18 mL
5 mM 0.3 mL 1.52 mL 3.04 mL

*The above data is based on the productmolecular weight 658.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16190
Actions Inhibitor
CAS No. 1430844-80-6
Formula C38H38N6O3S
M. Wt 658.82
Purity >98%
Synonyms A 1331852, A1331852
SMILES CC1=C(C=NN1CC23CC4CC(C2)CC(C4)C3)C5=C(N=C(C=C5)N6CCC7=CC=CC(=C7C6)C(=O)NC8=NC9=CC=CC=C9S8)C(=O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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