Fig. 1 · Structure
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A-192621
ETB Receptor Antagonist
A-192621 is a potent nonpeptide antagonist of the endothelin B (ETB) receptor, demonstrating an IC50 of 4.5 nM and a Ki of 8.8 nM. Its selectivity is notable, with a 636-fold preference over the endothelin A (ETA) receptor. This compound has been shown to promote apoptosis in pulmonary artery smooth muscle cells (PASMCs) and may contribute to elevated arterial blood pressure and increased plasma levels of endothelin-1 (ET-1). A-192621 is valuable for research applications involving endothelin signaling and cardiovascular physiology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 195529-54-5 |
| Applications | ETB Receptor Antagonist |
| Formula | C33H38N2O6 |
| Molecular Weight | 558.66 |
| SMILES | O=C([C@H]1[C@H](C2=CC=C(OCCC)C=C2)N(CC(NC3=C(CC)C=CC=C3CC)=O)C[C@@H]1C4=CC=C(OCO5)C5=C4)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.