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A-278637

KATP Channel Opener

A-278637 is a selective opener of KATP channels, characterized by an EC50 of 102 nM. This compound demonstrates specificity by not interacting with other ion channels, such as L-type calcium channels, or various neurotransmitter receptor systems. Notably, A-278637 exhibits enhanced functional selectivity for urinary bladder smooth muscle compared to vascular smooth muscle in vivo. It serves as a valuable tool for investigating overactive bladder conditions in research applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Opener
CAS Number	227609-66-7
Applications	KATP Channel Opener
Formula	C₁₇H₁₅BrFNO₃S
Molecular Weight	412.27
SMILES	O=S1(C2=C(CC1)NC(CCCC3=O)=C3[C@]2([H])C4=CC(Br)=C(C=C4)F)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.