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A-286501

Adenosine Kinase Inhibitor

A-286501 is a potent inhibitor of adenosine kinase, demonstrating an IC50 value of 0.47 nM. This carbocyclic nucleoside exhibits significant analgesic and anti-inflammatory properties, effectively reducing nociception in various animal models, including acute thermal pain, inflammatory pain induced by formalin and carrageenan, and neuropathic pain from L5/L6 nerve ligation and streptozotocin-induced diabetes. Additionally, A-286501 diminishes paw edema and myeloperoxidase activity in carrageenan-induced injuries, making it a valuable tool for research in analgesic and anti-inflammatory applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	483341-15-7
Applications	Adenosine Kinase Inhibitor
Formula	C₁₁H₁₄BrN₅O₂
Molecular Weight	328.17
SMILES	O[C@H]1[C@@H](C[C@@H]([C@H]1O)N)N2C3=NC=NC(N)=C3C(Br)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.