Fig. 1 · Structure
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A-30312
Drug Derivative
A-30312 is a drug derivative designed to reverse multidrug resistance by enhancing the cytotoxic effect of antitumor agents in resistant cancer cells. It functions by increasing the intracellular accumulation of therapeutic compounds and inhibiting their efflux mechanisms. Notably, A-30312 does not exhibit significant hypotensive effects, distinguishing it from traditional calcium antagonists, and its mechanism may operate independently of calcium transport inhibition. This compound is valuable for research in overcoming drug resistance in cancer therapy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 144092-65-9 |
| Applications | Drug Derivative |
| Formula | C19H21ClN2O |
| Molecular Weight | 328.84 |
| SMILES | COC1=CC2=C(C=C1)NC3=C2CN(CC3)CC4=CC=CC=C4.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.