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A-423579

H3 Receptor Antagonist

A-423579 is an orally active histamine H3 receptor antagonist with both antagonistic and inverse agonistic properties. It exhibits high affinity and selectivity for human and rat H3 receptors. This compound effectively reduces body weight in obese rodent models, resulting in decreased fat content, plasma leptin levels, and triglycerides. A-423579 is valuable for research into obesity and related metabolic disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	461045-17-0
Applications	H3 Receptor Antagonist
Formula	C₂₂H₂₅F₂N₃O
Molecular Weight	385.45
SMILES	CN([C@@H]1CCN(CCCOC2=C(F)C=C(C3=CC=C(C#N)C=C3)C=C2F)C1)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.