Fig. 1 · Structure
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A-424274
nAChR Agonist
A-424274 is a positive allosteric modulator of the α4β2 neuronal nicotinic acetylcholine receptor. This compound enhances the potency and efficacy of various nicotinic acetylcholine receptor agonists, making it a valuable tool in pain management research. In preclinical studies, co-administration of A-424274 with an α4β2 positive allosteric modulator has been shown to significantly improve the analgesic effects of ABT-594, demonstrating its potential for enhancing therapeutic outcomes in pain relief.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1335145-56-6 |
| Applications | nAChR Agonist |
| Formula | C14H15N3 |
| Molecular Weight | 225.29 |
| SMILES | [H][C@]12CN(C3=CC4=CC=CC=C4N=C3)C[C@@]1([H])NC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.