Documents & Downloads

A-582941 dihydrochloride

α7 nAChR agonist

A-582941 dihydrochloride is a selective AChR a7 partial agonist. It exhibits high affinity for both rat and human a7 receptors (Ki values are 10.8 and 16.7 nM, respectively).

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Biological Activity

Target & Activity

Target	Activity	Value
α7 nAChR		10.8 nM (Ki, for rat α7 receptors)
α7 nAChR		16.7 nM (Ki, for human α7 receptors)
5-HT3 Receptor	Ki	150 nM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
HEK293	EC50	> 100 μM	Agonist activity at human recombinant alpha4beta2 nicotinic acetylcholine receptor expressed in HEK293 cells assessed as changes in intracellular calcium level by FLIPR	[PMID: 19552432]
Oocyte	EC50	4.26 μM	Agonist activity at human recombinant alpha7 nicotinic acetylcholine receptor expressed in xenopus laevis oocytes by parallel oocyte electrophysiological assay	[PMID: 19552432]

Specifications

Manufacturer	Adooq Bioscience
Actions	Partial Agonist
CAS Number	848591-90-2
Applications	α7 nAChR agonist
Formula	C₁₇H₂₂Cl₂N₄
Molecular Weight	353.29
SMILES	CN1CC(CN(C2=NN=C(C3=CC=CC=C3)C=C2)C4)C4C1.[H]Cl.[H]Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Documents & Downloads

A-582941 dihydrochloride

Select a Size

Package Sizes

DMSO Solution