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A 71915

Catalog No.: A61956
ANP antagonist
A 71915 is a potent and competitive antagonist of the natriuretic peptide receptor A (NPRA), exhibiting a pKi value of 9.18. It effectively displaces [125I]ANP in a dose-dependent manner, with a dissociation constant (Ki) of 0.65 nM. In cellular assays, A 71915 demonstrates a significant inhibition of rat ANP-induced cGMP production in NB-OK-1 cells, making it a valuable tool for research into cardiovascular signaling pathways and related therapeutic applications.
A 71915 132956-87-7 ANP antagonist
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Size Price Stock Qty
1mg
$145.00
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5mg
$395.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionA 71915 is a potent and competitive antagonist of the natriuretic peptide receptor A (NPRA), exhibiting a pKi value of 9.18. It effectively displaces [125I]ANP in a dose-dependent manner, with a dissociation constant (Ki) of 0.65 nM. In cellular assays, A 71915 demonstrates a significant inhibition of rat ANP-induced cGMP production in NB-OK-1 cells, making it a valuable tool for research into cardiovascular signaling pathways and related therapeutic applications.
Product Information
Catalog NumA61956
FormulaC69H116N26O15S2
Molecular Weight1613.95
CAS Number132956-87-7
SequenceArg-Cys-{Cha}-Gly-Gly-Arg-Ile-Asp-Arg-Ile-{d-Tic}-Arg-Cys-NH2 (Disulfide bridge: Cys2-Cys13)
Sequence shorteningRC-{Cha}-GGRIDRI-{d-Tic}-RC-NH2 (Disulfide bridge: Cys2-Cys13)
SMILES[H][C@]12Cc3ccccc3CN1C(=O)[C@@]([H])(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@]([H])(NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(N)=O)NC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)CC)[C@@H](C)CC
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GPCR/G Protein > Natriuretic Peptide Receptor (NPR)