Fig. 1 · Structure
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A-77636 hydrochloride
Dopamine D1 Receptor Agonist
A-77636 hydrochloride is a selective and potent dopamine D1 receptor agonist with an antiparkinsonian profile, characterized by a pKi of 7.40 and a Ki of 39.8 nM. This compound is known for its long-lasting effects and is functionally inactive at the dopamine D2 receptor, making it a valuable tool for studying dopamine signaling and potential therapeutic interventions in Parkinson's disease. Its specificity and activity make A-77636 hydrochloride suitable for research focusing on dopaminergic systems and related neuropharmacological applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 145307-34-2 |
| Applications | Dopamine D1 Receptor Agonist |
| Formula | C20H28ClNO3 |
| Molecular Weight | 365.89 |
| SMILES | [H]Cl.NC[C@@H]1O[C@@H](CC2=C(O)C(O)=CC=C12)C34C[C@H](C5)C[C@H](C[C@H]5C4)C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.