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A-800141

MetAP2 Inhibitor

A-800141 is a selective inhibitor of methionine aminopeptidase 2 (MetAP2), exhibiting an IC50 of 12 nM. It demonstrates minimal inhibitory activity against MetAP1 with an IC50 of 36 μM. A-800141 has been shown to possess antiangiogenic and anticancer properties in various xenograft tumor models. Additionally, GAPDH serves as a biomarker for monitoring MetAP2 inhibition in research applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	681245-85-2
Applications	MetAP2 Inhibitor
Formula	C₂₄H₃₀N₂O₄S
Molecular Weight	442.57
SMILES	O=C(C1=C2CCCCC2=CC=C1NS(=O)(C3=CC=CC=C3/C=C\CN(CC)CC)=O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.