Fig. 1 · Structure
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A-81282
AT1 Receptor Antagonist
A-81282 is a selective antagonist of the angiotensin II AT1 receptor, exhibiting a pA2 value of 9.64 in rabbit aorta tissues. This compound effectively inhibits the binding of [125i]_Sar1_leu8_Angiotensin_II to rat liver membranes, demonstrating a pKI value of 8.505. A-81282 has been shown to possess antihypertensive properties, making it pertinent for studies focused on hypertension and cardiovascular research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 141872-46-0 |
| Applications | AT1 Receptor Antagonist |
| Formula | C23H23N7O2 |
| Molecular Weight | 429.47 |
| Synonyms | Abbott 81282 |
| SMILES | O=C(C1=CN=CN=C1N(CCCC)CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.