Fig. 1 · Structure
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A-943931
H4R Antagonist
A-943931 is a potent and selective antagonist of the histamine H4 receptor (H4R), exhibiting pKi values of 4.6 and 3.8 nM for human and rat H4R, respectively. This compound demonstrates significant anti-inflammatory and antinociceptive activities, making it a valuable tool for research into inflammatory disorders and pain management mechanisms. A-943931's specificity for H4R positions it as a promising candidate for further studies in therapeutic applications targeting this receptor.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1027330-97-7 |
| Applications | H4R Antagonist |
| Formula | C17H21N5 |
| Molecular Weight | 295.38 |
| SMILES | N[C@@H](C1)CCN1C2=C3CCCC4=CC=CC=C4C3=NC(N)=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.