Fig. 1 · Structure
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A-987306
H4 Receptor Antagonist
A-987306 is a potent, orally bioavailable histamine H4 receptor antagonist, exhibiting Kis of 3.4 nM for rat H4 and 5.8 nM for human H4. This compound demonstrates significant anti-inflammatory activity, as evidenced in a mouse peritonitis model. A-987306 serves as a valuable tool for researchers investigating the role of the H4 receptor in inflammation and related biological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1082954-71-9 |
| Applications | H4 Receptor Antagonist |
| Formula | C18H25N5O |
| Molecular Weight | 327.42 |
| SMILES | NC1=NC(N2CCNCC2)=C3CCC(O[C@]4([H])[C@@]5([H])CCCC4)=C5C3=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.