α-Androstenol (5α-Androst-16-en-3α-ol) is a steroid pheromone that acts as a positive allosteric modulator of GABAA receptors, enhancing GABA-activated currents in primary mouse cerebellar granule cells with an EC50 of 0.4 μM. It exhibits anxiolytic-like, antidepressant-like, and anticonvulsant effects in murine models. This compound can be utilized in research focused on the mechanisms underlying seizures and related neurological disorders.
α-Androstenol (5α-Androst-16-en-3α-ol) is a steroid pheromone that acts as a positive allosteric modulator of GABAA receptors, enhancing GABA-activated currents in primary mouse cerebellar granule cells with an EC50 of 0.4 μM. It exhibits anxiolytic-like, antidepressant-like, and anticonvulsant effects in murine models. This compound can be utilized in research focused on the mechanisms underlying seizures and related neurological disorders.
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