Fig. 1 · Structure
Documents & Downloads
α-Androstenol
GABAA Receptor PAM
α-Androstenol (5α-Androst-16-en-3α-ol) is a steroid pheromone that acts as a positive allosteric modulator of GABAA receptors, enhancing GABA-activated currents in primary mouse cerebellar granule cells with an EC50 of 0.4 μM. It exhibits anxiolytic-like, antidepressant-like, and anticonvulsant effects in murine models. This compound can be utilized in research focused on the mechanisms underlying seizures and related neurological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1153-51-1 |
| Applications | GABAA Receptor PAM |
| Formula | C19H30O |
| Molecular Weight | 274.44 |
| Synonyms | 5α-Androst-16-en-3α-ol |
| SMILES | [H][C@@]12CC=C[C@]1(CC[C@]3([C@]2(CC[C@]4(C[C@@H](CC[C@]34C)O)[H])[H])[H])C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.